Starring Jodie Foster and Anthony Hopkins, 'The Silence of the Lambs,' based on the novel of the same name by Thomas Harris, tells the bone-chilling story of a FBI trainee who enlists the help of one serial killer in order to track down a second killer. Foster and Hopkins picked up Best Actress and Actor Oscars, while the 1991 film won Best Picture. In total, the film received five Oscars.