Meredith is also seen riding a ferry boat in a tribute to her late husband, Derek Shepard (Patrick Dempsey), and the episode's opening scene ended with the show's original theme song, "Cosy in the Rocket,” by Psapp.
ET's Leanne Aguilera was with the cast of Grey's Anatomy as they celebrated their milestone episode at TAO in Los Angeles on Saturday.
"I mean, 300 episodes, I can't believe it," Caterina Scorsone, who first appeared in the series in season seven, marveled. "I remember when we were doing 250, and we were like, 'What?!'"
"When I first joined the show in season five, [I was a] Scottish actor straight from Scotland and they [had] just celebrated the 100th episode. At the time, I was like, 'How does anybody ever get to 100 episodes?'" Kevin McKidd added.