Copyright 2009 Bob D'Amico / ABC

"Grey’s Anatomy" stars Sara Ramirez and Chandra Wilson, "True Blood" stars Sam Trammell and Michelle Forbes, "Entourage" star Rex Lee, "Bored to Death" star Jason Schwartzman, "Dancing with the Stars"' Melissa Joan Hart and Mark Ballas, and Mayor Antonio Villaraigosa has RSVP'd that they will attend the 5th Annual GLSEN Respect Awards at the Beverly Hills Hotel in Beverly Hills, Calif.

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Copyright 2008 Bob D'Amico / ABC

"Grey's Anatomy" creator and head writer Shonda Rhimes is talking about the fates of Izzy, George and the Post-It wedding.

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Copyright 2009 Danny Feld / ABC

Will Katherine Heigl and T.R. Knight be checking out of Seattle Grace Hospital?

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Copyright 2008 Alberto E. Rodriguez / Getty Images

"Grey's Anatomy" creator Shonda Rhimes is commenting on the recent dismissal of actress Brooke Smith from the hit ABC show.

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Copyright 2008 Frazer Harrison / Getty Images

"Grey's Anatomy" star SARA RAMIREZ has struggled with weight issues for almost as long as she can remember. But that didn't keep her from becoming a success in a business where packing on the pounds is considered career suicide. In the January issue of Glamour magazine, the Tony® Award-winning actress talks frankly about her yo-yo weight loss -- down to a size six -- and gains -- up to a size 14.

A talented singer, Ramirez attended the Juilliard School in New York City, where, surrounded by skinny actresses and dancers, body-image issues came to the fore.

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Copyright 2007 Frank Ockenfels/ ABC / ABC

The third season premiere of "Grey's Anatomy" picks up right where the action left off at the end of last season, at the hospital's "senior prom" -- and the choices that the staff of Seattle Grace Hospital made at that time now have to be confronted.

Izzie (Katherine Heigl) has to come to terms with Denny's (Jeffrey Dean Morgan) death and the fact that she quit her surgical internship. Cristina (Sandra Oh) has to decide if she will stand by Dr. Burke (Isaiah Washington) now that there is a chance he won't be able to operate. And Meredith (Ellen Pompeo), who had sex with Dr. Derek Shepherd (Patrick Dempsey) in one of the exam rooms at the prom, has to chose between the handsome surgeon and her boyfriend Finn (Chris O'Donnell), aka Dr. McVet.

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This Sunday night "Grey's Anatomy" will air the first of a two-part finale, with the second part airing on Monday, rather than the following week, in which Cristina (SANDRA OH) takes over the ER, Izzie (KATHERINE HEIGL) and Burke (ISAIAH WASHINGTON) feel pressure to find Denny (JEFFREY DEAN MORGAN) a new heart and Derek (PATRICK DEMPSEY) holds the life of a friend in his hands.

"People will be happy with the end result," Patrick tells ET's MARK STEINES, who made a visit to the set to try to sleuth out some spoilers -- to no avail. "It is what they want to see. We had a memo sent to us that we can't talk about it."

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Each year ABC picks one of its hot shows to air following the Super Bowl, and this year's winner of the coveted timeslot is "Grey's Anatomy," a medical drama that focuses as much on the love lives of the five interns who are its stars as it does the cases to which they are assigned.

"I planned the episode knowing that it was possible that it could be the Super Bowl episode, but also knowing that we would do the episode whether or not it was on Super Bowl Sunday or not," explains SHONDA RHIMES, executive producer and creator of "Grey's Anatomy."

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