Copyright 2008 Blue Sky Studios / Twentieth Century Fox

JIM CARREY pulled another box office hit out of his hat, as his animated 'Horton Hears a Who!' topped the box office with this year's biggest opening so far: $45.1 million, according to preliminary studio estimates.

Carrey, in his second DR. SEUSS film (he also starred in 'How the Grinch Stole Christmas'), plays Horton the elephant, who hears voices coming from a speck of dust. Horton soon discovers, to his amazement, that a planet containing a village called "Who-ville" is located in the infinitesimal grain of dust and it's up to him to protect the people who live there. STEVE CARELL voices Mayor of Who-ville, while DANE COOK, SETH ROGEN, CAROL BURNETT, JAIME PRESSLY, ISLA FISHER, JONAH HILL ('Superbad'), WILL ARNETT ("Arrested Development") and AMY POEHLER ("Saturday Night Live") also provide voices.

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Copyright 2008 Warner Brothers / Warner Brothers

'10,000 B.C.''s box office was anything but prehistoric as the period epic premiered in first place with a haul of $35.7 million, according to preliminary studio estimates.

The ROLAND EMMERICH film follows a mammoth hunter in the year 10,000 B.C. as he goes on a quest that could make or break his tribe. STEVEN STRAIT and CAMILLA BELLE star in the pic.

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Copyright 2008 New Line Cinema / ETonline.com

WILL FERRELL's latest spoof comedy, this time about the world of semi-professional basketball in the 1970s, racked up a first place finish at the box office this weekend, with a haul of $15.2 million, according to preliminary studio estimates.

'Semi-Pro' finds Will playing Jackie Moon, a former NBA benchwarmer who returns to his rag-tag team in the American Basketball Association, the Flint Michigan Tropics, in an attempt to coach them to the big leagues. The movie also features WOODY HARRELSON, ANDRE BENJAMIN, MAURA TIERNEY, ANDY RICHTER and JACKIE EARLE HALEY.

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