Tra la la la la la! In the 3D movie, the Smurfs wind up in the human world after their archenemy Gargamel (Hank Azaria) forces the little blue creatures out of their village. Chaos ensues when the Smurfs land in the middle of New York City's Central Park. Neil Patrick Harris, Jayma Mays and Sofia Vergara are live-action humans, while Katy Perry provides the voice of Smurfette. The characters originated in a Belgian comic strip back in 1958.