Who's in it: Matt Damon, Gwyneth Paltrow, Laurence Fishburne, Kate Winslet, Jude Law, Bryan Cranston, Marion Cotillard Director: Steven Soderbergh (Traffic, Ocean's Eleven) The Plot: Matt is an everyday parent whose life is changed forever when his wife contracts a lethal virus. As the fast-moving pandemic grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself. Reason to see it: It's been 16 years since Outbreak beat the bestseller The Hot Zone into theaters, scaring the bejeezus out of filmgoers and prompting people to wash their hands thoroughly 20 times a day. Contagion's got an A-list cast in the viral line of fire, plus a cool international feel, shot on locations around the world including Hong Kong, Chicago, Atlanta, San Francisco, Abu Dhabi, London and Geneva. To help you decide: Watch the trailer.