Cobie Smulders Talks Working With Tom Cruise on 'Jack Reacher 2': 'We're on the Run for This Entire Movie'

Cobie Smulders is showing audiences a side of her they haven't seen before in the Jack Reacher follow-up, Jack Reacher: Never Go Back, and ET has a sneak peek at scenes from the movie!

The sequel, based on author Lee Child's 18th book in the bestselling Jack Reacher series, finds Jack back at the headquarters of his old unit, only to discover he's now accused of a homicide from 16 years ago.

WATCH: How to Drive & Fight Like Jack Reacher!

Smulders plays Major Susan Turner, who has taken Jack's place commanding the military police in his absence.

"He's alone and he's sort of in his element and then he couples up with me and all hell breaks loose," Smulders says of Cruise's character. "We're on the run for this entire movie."

Real-life danger struck the set while filming last fall in Louisiana when one of the wardrobe trailers went up in flames. The blaze erupted spontaneously when Cruise was in his own trailer getting makeup done for the next scene just yards away.

WATCH: Tom Cruise's Best Action Movies

At the time, an eyewitness told ET that the crew was able to partially put out the fire, which helped contain it before four firetrucks arrived to the scene and finished the job.

Jack Reacher: Never Go Back opens Oct. 21.