Chelsea Handler on Demi: 'That's a Sad Situation'

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Chelsea Handler adds comic relief to the already funny action-comedy This Means War, but she gets serious about Demi Moore's recent troubles, who was a guest on Chelsea Lately during her "Big Interview Special."

Demi Moore To Be Treated for 'Exhaustion'

"Obviously it's a very delicate situation, it sounds like," Chelsea tells ET's Nancy O'Dell. "I don't like anything that's really that serious. Like anything that's life-threatening, I don't think that's fun to make fun of. I mean, that's a sad situation. With her children, and, you know, I just hope that she gets whatever help she needs."

Demi Moore 911 Call: The Details

Asked if she thinks the recent 911 call should have been released, Chelsea replies, "No, I mean, but this town is so gross. I mean, people do that all the time. I like doing my show because we get to have fun and make light of how silly the gossip is. When it becomes a serious matter, like with Lindsay Lohan, or something, that's not funny anymore. Now it's serious."

Love Gone Bad: Ashton & Demi in Happier Times

In This Means War, in theaters on Valentine's Day, Chelsea plays the best friend of Reese Witherspoon, who finds herself in the middle of an explosive love triangle with deadly CIA operatives Chris Pine and Tom Hardy.