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What are Oprah Winfrey's words to live by?

The Queen of Daytime shares her "101 best pieces of advice ever" with O Magazine readers for the October 2012 issue, and we're behind the scenes of the stylish cover shoot!

Watch the video above to hear Lady O spill on her best (and worst) life/career advice, plus Oprah divulges the three people she trusts implicitly.

VIDEO: Oprah on Difficulties and Mistakes at OWN

And in keeping with the theme of living your best life, Oprah is hosting an interactive day of seminars and workshops in Los Angeles, CA on October 20th. Tickets to the O You! celebration can be purchased here.