The two-hour event, co-hosted by Swank, will put a spotlight on the joys that rescue dogs have brought into their owners' lives, and will even include testimonies from celebrities with rescue dogs.
Special guests will include Josh Duhamel and wife Fergie, Scarlett Johansson, Miranda Lambert, Kristen Bell, Paula Abdul, Betty White, LeAnn Rimes, Ke$ha and Carrie Ann Inaba.
Above: Kristen Bell with Lola and Mr. Shakes
The show will also include awards in categories such as Cutest Puppy, Best Celebrity/Dog Lookalike, Guiltiest Dog, Best Licker, Smartest Dog and Best Viral Dog Video.
Above: Carrie Ann Inaba with Lola
"I have long been an advocate for animal adoption and know first-hand the immense joy a shelter animal brings to our lives," said Swank, who also executive produces the show. "Yet, every year more than four million animals are euthanized because of overcrowding in shelters. We are so fortunate to have an animal advocate in the FOX network that not only sees the need for more awareness surrounding this issue, but is willing to set aside a two-hour block for this important cause. This partnership will change the path of a soul for thousands of animals looking for their forever home."
Above: Josh Duhamel, Cesar Millan and Fergie with Josh and Fergie's dog Zoe.
The Great American Dog-a-Thon, also executive produced by Michael Levitt, airs Thursday, November 27 at 8 p.m. ET on FOX.