"I'd really like to address something that is weighing very heavily on my heart," Rancic began.
The Fashion Police host's latest apology on Tuesday's E! News comes a day after she made off-color comments about Zendaya's Oscar look. On Monday's Fashion Police, Rancic said in her critique of Zendaya's hairstyle, "I feel that she smells like patchouli oil…or weed."
Rancic wrote an apology shortly afterwards on Twitter, saying that her comment was in reference to the "bohemian chic look" and that it had "nothing to do with race."
Rancic's new message for the 18-year-old singer-actress? "I want to say to Zendaya that I am so sincerely sorry."
"I didn't intend to hurt anybody, but I've learned it's not my intent that matters. It's the result," she continued.
On Monday night, Zendaya didn't take Rancic's remarks lightly, posting a lengthy explanation why on her Instagram to voice her feelings.
"To say that an 18 year old young woman with locs must smell of patchouli oil or 'weed' is not only a large stereotype but outrageously offensive," Zendaya wrote. "There is already a harsh criticism of African American hair in society without the help of ignorant people who choose to judge others based on the curl of their hair."
While Rancic says the incident taught her to be more aware of stereotypes, her fellow co-host Kelly Obsourne was "questioning" staying on Fashion Police over the drama.
She tweeted out several messages defending her "friend" Zendaya before Rancic issued her second apology.