The 43-year-old actress posted a photo on Instagram of the firefighters trying to get the blaze under control:
"NYC's finest trying to put out the flames to mine n many others apartments," she wrote under the photo. "Speechless…"
The initial blast was reported at 3:17 p.m. on Thursday. According to the Associated Press, the explosion and ensuing fire leveled three apartment buildings and damaged a fourth. In total, about 50 units were destroyed. The New York Times reported 19 people were injured and at least two are missing.
Mayor Bill de Blasio said in a press conference the initial explosion that started the blaze may have been gas-related.
De Matteo, who lived at the apartment for more than two decades, posted a photo of the aftermath and wrote, "A hole where my NYC home of the last 22 years once stood… RIP 123 2nd Avenue."
The actress most recently appeared on ABC's Agents of S.H.I.E.L.D.
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