The 65-year-old dermatologist to the stars was found dead at his Miami, Fla. mansion after police were called to investigate an attempted suicide the morning of Sunday, April 5.
The doctor -- who referred to himself as "Baron of Botox" in a 2009 interview with ET -- had an impressive roster of celebrity patients, including Madonna, Kelly Ripa and model Stephanie Seymour. The Live With Kelly and Michael host mourned the loss of her friend, tweeting, "My heart is breaking for the loss of Dr. Fredric Brandt. My friend. You will be missed forever and in my heart even longer."
His team confirmed his passing on Instagram, writing, "His warmth, kind heart, laughter and talent will be sorely missed by all whose lives he touched. He made the world a brighter and more beautiful place. His generous and loving spirit will live on."
Most recently, actor Martin Short played an exaggerated version of a cosmetic surgeon with similarities to Dr. Brandt on Netflix's The Unbreakable Kimmy Schmidt, co-created by Tina Fey and Robert Carlock. Dr. Brandt was reportedly "devastated" by comparisons made between himself and the fictional character on the show.
"Are they responsible? Absolutely not," Miami Herald gossip columnist Lesley Abravanel told ET. "It was a parody. Again, they never said it was based on him. I spoke to a friend of the doctor's this morning who said unfortunately while it might have been taken by some people as a compliment, he just took it very personally and very hard."
In addition to his thriving practices in both Manhattan and Coral Gables, Fla., Dr. Brandt also hosted a weekly radio show on Sirius XM and had a skincare line.
He is survived by his brother Paul and his beloved dogs -- Benji, Surya and Tyler.
ET has reached out to Tina Fey, Martin Short, Madonna and Netflix, but they all declined to comment.