Vice President Joe Biden's Son Beau Dies at 46

Joseph R. Biden III, the son of Vice President Joe Biden, has passed away.

The family made the announcement that their son, known as Beau, died at the age of 46 on Saturday after battling brain cancer.

"It is with broken hearts that Hallie, Hunter, Ashley, Jill and I announce the passing of our husband, brother and son, Beau, after he battled brain cancer with the same integrity, courage and strength he demonstrated every day of his life," the Vice President said in a statement. "Beau embodied my father's saying that a parent knows success when his child turns out better than he did."

For nearly a decade, Beau worked as a prosecutor in Philadelphia before becoming Delaware's attorney general in 2006, a position he had for two terms. He also served a one-year deployment in Iraq in 2008 and was awarded the Bronze Star.

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Beau leaves behind a wife, Hallie, and two children, Natalie, 11, and Hunter, 9.

This is the second tragic family loss for Joe. He lost his first wife, Neilia and 1-year-old daughter Naomi in a car accident in 1972. Beau and his brother, Hunter, survived the crash. Joe remarried in 1977 to Dr. Jill Biden.

President Obama expressed his sadness in a statement for the Biden family. "Michelle and I are grieving tonight. Beau Biden was a friend of ours. His beloved family – Hallie, Natalie, and Hunter – are friends of ours. And Joe and Jill Biden are as good as friends get," he said. "Beau Biden believed the best of us all. For him, and for his family, we swing our lanterns higher."

According to CNN, Beau is the first child of a sitting President or Vice President to die since John F. Kennedy's son Patrick died two days after birth in 1963.

Many politicians and celebrities are expressing their condolences through Twitter tonight.