The magazine asked 150 stars to snap selfies for the publication, including Madonna, Miley Cyrus, Victoria Beckham, Kim Kardashian West, Jennifer Lopez, Selena Gomez, Zayn Malik, and Mert Alas, who appear on the covers.
The #ME issue also features self portraits from Laverne Cox, Diplo, A$AP Rocky, Riccardo Tisci, Ai Weiwei, Snoop Dogg, Cher, Kendall Jenner, Jeremy Scott, Carine Roitfeld, Alexander Wang, Zoe Kravitz and Willow Smith.
The magazine's 1969 founder, artist Andy Warhol, seems to have predicted the rise of social media when he said, "In the future, everyone will be world famous for 15 minutes." He later corrected himself, "In 15 minutes, everyone will be famous."
"Social media is where we live now, no question. And if Andy were still alive, he'd have a huge presence online," Interview's editorial director Fabien Baron said of Warhol, who loved snapping Polaroid images in his day. "In much the same way we at magazines put together a story and create a character or narrative, everyone can now package themselves as they see fit. Everyone can invent their own image and create their own story. "
Kardashian is a social media heavyweight and selfie pioneer, deserving of a cover. The 34-year-old reality star has more Instagram followers -- an estimated 44.8 million -- than anyone else on the photo sharing site. She even tops Beyonce.
While promoting her self-portrait book, Selfish, Kardashian revealed her secret to taking the perfect selfie.
"If it’s not good lighting, then you do the more moody vibe," she explained. "And you just take about 500 pictures until you get the right one."