From James Corden to Jimmy Kimmel, here's a look at all the one-liners from the hosts' opening monologues.
"There are a lot of important and life-threatening and world changing things going on lately; sometimes it seems like more than ever. But none of them are as foundation shaking as the news we received about Brad and Angelina
today," Kimmel began. "As I'm sure you've heard, Angelina Jolie filed for divorce from Brad Pitt, and of course, all the celebrity gossip magazines are claiming victory. You know, they broke this story. They broke this story every week for the last 11 years over and over and over again -- until finally, it came true."
Kimmel quipped, "Apparently the reason they're getting divorced is she talked about Fight Club, and [Pitt] specifically asked her not to do that."
"Now that this has happened, you wonder what else the tabloids have been right about," he continued. "Are [Ben Affleck] and [Jennifer Lopez] back together? Was [Kim Kardashian] dumped on her first anniversary? Is Barack Obama gay? I mean, he must be; they wouldn't put it on the cover if it wasn't true. Anyway, our thoughts are with Brad and Angelina, and with all of us. It's always hard when two people you don't know and have no personal connection to split up."
The Late Late Show With James Corden
"It came out that Brad Pitt and Angelina Jolie are filing for divorce and will end their relationship of 12 years." Corden explained. "I'm taking this news especially hard because I named my daughter Brangelina. It feels like a mistake now."
He added, "But this breakup couldn't come at a worse time. In the face of a Donald Trump presidency, Brad and Angelina's marriage was the last hope for immigrants to be welcomed into this country."
Late Night With Seth Meyers
Host Seth Meyers sang the Friends theme song when talking about the divorce. Putting up a photo of Pitt's ex-wife, Jennifer Aniston, he joked, "Said one observer, 'So no one told you life was gonna be this way.'"
The Tonight Show Starring Jimmy Fallon
"It's pretty scary when even Angelina Jolie and Brad Pitt are like, 'Eh, I can do better,'" Fallon quipped.
Late Show With Stephen Colbert
"They're just gonna be Jolina and Bran now," Colbert joked, adding that Jolie cited "irreconcilable attractiveness" as the reason she filed for divorce.
The Daily Show With Trevor Noah
"I can't believe Angelina is leaving Brad," Noah reacted to the news. "So no more Brangelina? Is this a Brexit? Is that what this is, a Bradsit? Angeleavya? What is this? But seriously, you think you guys are devastated? Think about how Africans are feeling right now. These two were our only way out. How do you think I got here?"
"The big story today is celebrity news, Brad Pitt and Angelina Jolie are getting a divorce," Conan O'Brien announced. "They'll share custody 50-50: He'll take 50 kids, she'll take the other 50."
In addition to the late night hosts cracking jokes, the Internet went wild with gifs and memes following news of the split, particularly aimed at Aniston
. Take a look: