The 41-year-old actress has been married to husband Ryan DeBolt since 2012.
Sara Ramirez is speaking her truth.
The 41-year-old actress revealed that she's bisexual while giving a speech at the True Colors Fund's 40 to None Summit in Los Angeles on Saturday.
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"So many of our youth experiencing homelessness are youth whose lives touch on many intersections – whether they be gender identity, gender expression, race, class, sexual orientation, religion, citizenship status," she said.
"Because of the intersections that exist in my own life: Woman, multi-racial woman, woman of color, queer, bisexual, Mexican-Irish American, immigrant, and raised by families heavily rooted in Catholicism on both my Mexican & Irish sides," she continued, "I am deeply invested in projects that allow our youth’s voices to be heard, and that support our youth in owning their own complex narratives so that we can show up for them in the ways they need us to."
Ramirez also took to Twitter to confirm the news.
"#40ToNoneSummit #SpeakingMyTruth!" she wrote. "Will post full video of speech soon! #ThankYou @TrueColorsFund #WomanOfColor #Bisexual #Queer #Immigrant."
Watch the Grey's Anataomy star's powerful speech below, courtesy of the True Colors Fund:
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Fans were quick to applaud the actress for her courage.
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Ramirez, who married husband Ryan DeBolt in 2012, has never spoken openly about her sexuality, despite playing a bisexual character, Callie Torres, on Grey's Anatomy. The actress announced she was leaving the show in May, after 10 seasons.
"I'm deeply grateful to have spent the last 10 years with my family at Grey's Anatomy & ABC but for now, I'm taking some welcome time off," she wrote on Twitter. "Shonda [Rhimes has] been so incredible to work for, & we will definitely continue our conversations!"
See more in the video below.