It's here! ET has a first look at "4 Minutes," the pulsating and hypnotic debut single from MADONNA's new disc, Hard Candy, featuring co-producer JUSTIN TIMBERLAKE -- and currently No. 1 on iTunes!

When asked about the "4 Minute Fever Phenomenon" that's taking the world by storm, Madonna commented, "Goody goody gum drops." See any B-12 shots?

Hard Candy will have a global release on April 28 and a US release on April 29.