ET has your first look at the new ad from The ONE Campaign that has united Matt Damon, Cindy McCain and Michelle Obama for the same cause, to make worldwide poverty and disease a major issue in this year's presidential election.

The 30-second spot called "Voices" features Damon, who has traveled twice to Africa with ONE, speaking directly to the camera, joined by the voices of Cindy McCain, Michelle Obama and New York City mayor Mike Bloomberg.

"The ONE Campaign isn't about taking sides, it's about taking action," Damon said. "America is saving millions of lives in the poorest parts of the world -- I saw it myself in Zambia and Tanzania."

Michelle Obama applauds ONE, saying we have a "moral obligation to help those across the world." Cindy McCain says she is "proud" of ONE's achievements and adds, "there's still more to do." The non-partisan effort has placed 41 million kids in school and saved the lives of 3 million children from preventable disease.

The new ad can be seen at www.ONE.org and will run on TV starting Aug 24.