Elizabeth Reaser is a busy actress: The former "Grey's Anatomy" star has an all-new romantic comedy, "The Ex List," premiering Friday night on CBS, and this November she's in one of the most anticipated movies of the year -- 'Twilight'! Tonight, Elizabeth's on the new ET set to talk love and vampires with our own Mark Steines.

"I had no idea the extent of this fan base and how excited they are," Elizabeth tells Mark of the book-turned-movie. "My dad is a substitute teacher in a high school in Michigan and he's with kids all the time, and he says, 'It's really big time.' According to him, he has a lot more clout in school now, so that says a lot."

In the movie, Elizabeth plays Esme Cullen, a member of the Cullen clan who is a vegetarian vampire, or what Elizabeth calls, "a conscientious vampire."

"That's what's amazing about the book and the series," explains the 33-year-old star, "is that this family of vampires, they try to resist drinking human blood. They kill wild boars and mountain lions and things."

In "The Ex List," Elizabeth plays Bella, a woman who finds out from a psychic that she's already dated the man she's destined to marry, so she assembles a list of her exes in search of her true soul mate.

"I think it's really about finding the one," says Elizabeth. "I do think she wants to get married, but I think it's really more about finding love and connection."

Of course, Elizabeth has to kiss a lot of frogs -- again -- to find her prince, and she laughs, "It's a lot of dudes. It's rough -- no, it's really kind of overwhelming! I feel a little embarrassed in front of the crew because they're the ones who are there every week seeing me [make out with a new guy]."

Watch ET for more with Elizabeth Reaser!