ET has learned that "The First Lady of Star Trek," actress Majel Barrett Roddenberry, has passed away due to complications from Leukemia. She was 76.

According to a statement from her family, the wife of late "Trek" creator Gene Roddenberry died early Thursday morning in Los Angeles surrounded by family and friends.

Majel was perhaps best known as Nurse Chapel on the original "Star Trek" series, which ran from 1966 to 1969, as well as playing counselor Deanna Troi's mother, Lwaxana Troi, in "Star Trek: The Next Generation" and the providing voice of the USS Enterprise computer in almost every incarnation of the series, including J.J. Abrams' new big-screen take on 'Star Trek,' in theaters this coming summer.

Majel's marriage to Gene Roddenberry earned her the title of "The First Lady of Star Trek," and she was considered to be Gene's creative muse and served as an integral part of the show's continued legacy after his death in 1991.

Majel's family has asked that in lieu of flowers, donations be made in her name to the CARE Organization or Precious Paws, both of which share her love for animals and dedication to animal rescue.

Funeral details are pending and a public memorial will be scheduled sometime after Christmas.