ET's Mark Steines is on location in Geneva, Switzerland with Tom Hanks and director Ron Howard in the most unlikely of places that serves as the setting for the beginning of the action in 'Angels and Demons,' the highly anticipated follow-up to 'The Da Vinci Code'!

Filming took place at CERN, the real-life nuclear research facility featured in Dan Brown's compelling book and movie. Tom was in a playful mood with the nuclear physicists that work at the plant when he arrived, asking questions like, "With the super collider, can you reheat a cup of coffee?"

The plot of the movie is set in motion with the discovery of the first dead body -- a respected physicist, his chest branded with the symbol of the Illuminati -- leading to a conspiracy involving none other than the use of anti-matter itself to destroy the Vatican.

"It was fascinating working on 'Da Vinci Code,' but with 'Angels and Demons,' this is a very modern contemporary thriller; it's very much about the moment," says Ron.

Our Mark Steines also donned a hard hat and descended 30 stories into the depths of the earth to get a firsthand look at the incredible hardware at the facility and meet the physicists responsible for the research to recreate the origins of The Big Bang itself!

"All those particle physics groupies that are kind of like Deadheads in a lot of ways, they just are on a caravan, they come here all the time," jokes Tom. "They're out front selling T-shirts and glow sticks -- that are made of anti matter by the way, so they will glow for a long, long time."

The new movie from Oscar winners Tom, Ron and producer Brian Grazer hits theaters everywhere May 15.

Watch ET for more exclusive coverage and interviews from the 'Angels and Demons' set!