Thursday night was no exception, when the 41-year-old comedian honored Jolie's divorce lawyer, Laura Wasser, at the 23rd anniversary celebration of A Place Called Home (APCH) -- a South Central Los Angeles-based organization providing a safe haven and programs to improve the lives of underserved youth. Handler praised Wasser's efforts for the charity, but also took a shot at her client's headline-making split from Brad Pitt.
"She's very dynamic, she's very principled, and she's a very accomplished human being," Handler said of Wasser. "And she's such a humanitarian, that she's currently negotiating Brad Pitt's emancipation, so ..."
"Speaking of children that need help ... " she joked immediately after her Jolie quip.
ET spoke with Handler at the event, where she talked about her close friendship with Wasser.
"She's been on my show a bunch of times, but we've met through, like, Pilates instructors," Handler told ET's Kevin Frazier about the high-powered celebrity attorney, calling her a "girl's girl." "She comes on my show to give us legal advice about sexual harassment in the workplace. Ummm... is it OK to hit an employee? It's not. You're not supposed to be high at work. I didn't know that either."
And although she had no issue dissing Jolie on stage, Handler also told us she's erasing the word 'hate' in her vocabulary given the recent controversial 2016 presidential election.
"It's a very important time to be a woman," she said. "It's a very important time to be an American, and we need to bridge the gap between whatever has divided us this election. There's a big problem. We have a big problem in this country and I want to do something good."
"We're gonna gather strength and galvanize, and figure out a way to talk to people who disagree with us and not spew hate at each other," she added about her plans for the future. "I'm extricating that word from my vocabulary. I'm no longer using it. We need to love each other."
"There are rumors that part of the problem was Brad was allegedly drinking and smoking too much weed," Handler said on her Netflix show, Chelsea. "I wonder why he needed to self-medicate. Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages?"
"Oh yeah, because he married a f**king lunatic, that's why!" she continued.
During her 2013 appearance on Watch What Happens Live!, Handler likened 41-year-old Jolie to a "demon."
"She seems like a demon," Handler said. "It has nothing to do with Jennifer. As a woman, I know when you see somebody walking across the room that's a bad girl. I just don't like Angelina Jolie. I don't think she's a girl's girl. I like girl's girls!"