Rest in peace, Mary Tyler Moore.
The iconic TV actress died on Wednesday, Moore's rep confirms to ET.
"Today, beloved icon, Mary Tyler Moore, passed away at the age of 80 in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine," read a statement from Moore's longtime representative, Mara Buxbaum. "A groundbreaking actress, producer, and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile."
Moore's death was caused by cardiopulmonary arrest after she had contracted pneumonia, her rep confirms.
The actress made her last public appearance on an episode of ABC's Katie with Katie Couric in 2013, where she reunited with her former Mary Tyler Moore Show co-stars Valerie Harper, Betty White, Cloris Leachman and Georgia Engel ahead of her guest-starring spot on Hot in Cleveland.
ET last spoke with Moore at the press conference for her episode of the TV Land comedy, where she opened up about reuniting with Harper.
"It's wonderful [to reunite with Harper], but it makes me sad too. It makes me feel, well, why don't I have this in my current life? Where are all these friends, buddies, and co-workers, and people who loved each other? Why can't they be around? Or maybe they can," she said, though noting that she's usually a "very happy person."
"My husband has always been very good at getting me out of myself when I get down and depressed and all of that -- never seriously," she confessed. "So, I am basically a very happy person."
Moore had battled type 1 diabetes since the early run of The Mary Tyler Moore Show, and underwent elective brain surgery in 2011 to remove a benign meningioma.