"I think I'm different," Meester confessed of her evolution since Gossip Girl.
"I started Gossip Girl 10 years ago when I was 20, and I'm 30 now," she continued. "I loved doing it, and now I'm doing something else that I love, and something new that's a little bit more my taste as a 30-year-old, something I've grown into."
"I feel so lucky that I can have such amazing fans, and they either grew up with [the show] or they're growing up with it now. I've also heard people say, 'Oh, we watch that as a throwback,'" she said.
While we're not sure Gossip Girl is quite on Throwback level just yet -- the CW series ended in 2012 – Meester has definitely come a long way. The actress secretly married The O.C. star Adam Brody in February 2014, just three months after their engagement, and welcomed their first child, daughter Arlo Day, in August 2015.
Fox's Making History marks her first regular role since giving birth -- which Meester says speaks volumes about the time travel comedy.
"When I went into [the show], and when I decided that I wanted to work consistently on something [since becoming a mom], I had criteria. I read other [scripts] too, but this was just the one. It was love at first sight," she explained.
Meester stars as Paul Revere's oldest daughter, Deborah, in the upcoming show, which centers on a professor who creates a device that allows him and his colleagues to change history and improve their lives. It's a far cry from Blair, but a role the actress says she is "proud" to play.
"I'm proud to work on a show that uplifts the female lead and has a not-so-subtle yet approachable commentary on the treatment and mistreatment of women throughout the ages," she said.
Though Meester and Brody have been notoriously private with their relationship, the two recently made a rare public appearance together at a Golden Globes after-party. See more in the video below.