After thanking his fans and the people behind the scenes who've helped him during his career, the beaming star took a moment to share some words of support and wisdom with his young admirers.
"I wrote this song because I wanted it to be about inclusion and about being together," Timberlake said. "I want to take this opportunity to speak to young people… If you are black or you are brown or you are gay or you are lesbian or you are trans -- or maybe you're just a sissy singing boy from Tennessee -- anyone that is treating you unkindly, it's only because they are afraid or they have been taught to be afraid of how important you are."
"Because being different means you make a difference. So, f**k 'em," he added to an eruption of cheering.
"You are young -- as I once was -- but do not think for a moment that what you do doesn't count. It does," Timberlake told the audience. "Not just to you but to the world and your generation who will someday inherit this world from [us] old timers." Check out the video below to hear more about his rousing speech.