The gala bash, presented by Hyundai, will be held at the Beverly Hilton in Beverly Hills, California. The Real Housewives of Beverly Hills star and best-selling dance music artist is set to perform a number of her hits.
On Monday, Jayne made her DWTS debut alongside pro dancer Gleb Savchenko, where the pair danced a salsa to her own popular dance track, "XXpen$ive," which she will also be performing at the after party.
Jayne is among several big name stars who will be appearing at this year's Awards ceremony, including The Hunger Games' Josh Hutcherson, Orphan Black star Tatiana Maslany, and Victoria Justice.
Comedian Cameron Esposito is hosting the big event, and Empire's Jussie Smollett will lead a tribute to Orlando's LGBTQ community with a special performance by Cynthia Ervio.
Oscar winner Patricia Arquette will also be honored at the show, with GLAAD's Vanguard Award, recognizing her efforts as an outspoken ally and supporter of the LGBTQ community.
Only ET will be backstage at the Los Angeles awards ceremony, which will honor film, television and media in 21 English-language categories and 11 Spanish-language categories. GLAAD will be holding a second ceremony in New York City on May 6.