Charlie Murphy, Eddie Murphy's older brother and a staple on Chappelle's Show, has died, ET can confirm.
A manager for Murphy tells ET that the comedian died Wednesday morning at New York Presbyterian Hospital from leukemia. His death was unexpected.
Murphy was 57 years old.
On Wednesday, the Murphy family sent out a statement, thanking fans for their support.
"Our hearts are heavy with the loss today of our son, brother, father, uncle and friend Charlie," the statement reads. "Charlie filled our family with love and laughter and there won't be a day that goes by that his presence will not be missed. Thank you for the outpouring of condolences and prayers. We respectfully ask for privacy during this time of great loss for all of us."
The late comedian's last tweet was on Wednesday morning, inspiring his fans to work hard.
Murphy recently toured with Cedric the Entertainer, Eddie Griffin, George Lopez and D.L. Hughley on "The Comedy Get Down" tour. Aside from co-writing some of Eddie Murphy's movies, including Norbit, he is perhaps best known for his sketches on Comedy Central's Chappelle's Show. Murphy famously recounted his days hanging out with his older brother in Hollywood, as well as the late Prince and the late Rick James.
He is survived by his two children with his late wife, Tisha Taylor Murphy, who died in 2009 from cervical cancer. He also had a child from a previous relationship.
A number of Murphy's fellow comedians have taken to social media to react to the sad news, including Kevin Hart, Mike Epps and George Lopez.
Wow....This is crazy. All I can say is RIP. Thank you for not only being a friend but for believing in me when I was young in this comedy game. Charlie Murphy did the rewrite for the first movie that I ever did called "Paper Soldiers"....His stories were legendary & unbelievable & heartfelt. I'm lucky to have know you and I'm even luckier to be able to say that I was a friend. You will be missed man. #RIPCharlieMurphy
This is a text message that Charlie sent us from a recent @comedygetdown Show @realdlhughley @cedtheentertainer " Great seeing you guys and living the magic last night. Great show brothers!!!!! ( I'm heartbroken at the passing of our brother Charlie . In relationships you never want to leave anything unsaid , our conversations before shows and after shows we all told each other and Charlie how we felt ! Keep his family in your thoughts and in your prayers and keep a space for Charlie in you're heart #Chingon I love you Charlie .#CHARLIEMURPHY 👊🏽
Today we lost a #RealOne. @therealcharliemurphy was a bad man and funny af. He was honest and straight shooter, no BS kinda dude, awesome Father and family man. Had a gregarious laugh that would make you laugh, he stood on his own 2 feet as a man and as a comic even in the shadows of the brother of one of the greatest to have ever done it. Listening to Charlie tell stories of his life was truly one of my greatest past times. It's why I love this pic. Touring with him these past few years on the #ComedyGetDown was indeed an honor. Though I am sadden by your passing. I pray for all of your loved ones his children and that his soul Rest In Peace. Love you brother C.T.E
Terribly saddened ... Charlie— Paul Mooney (@PaulEalyMooney) April 12, 2017
This one hurts. RIP Charlie Murphy. Always 💯 https://t.co/V9XfsEzXHu— Gary Owen (@garyowencomedy) April 12, 2017