Depp will be portraying Captain Jack Sparrow for a fifth time on the big screen when Dead Men Tell No Tales
hits theaters on May 26, but he's portrayed his beloved character several times off camera when visiting children's hospitals
around the world.
"Wherever I go, I bring Captain Jack in a box. Jack in a box," he tells DeGeneres. "You meet all these kids who are dealing with very adult illnesses, and you see this incredible courage on their faces, and it's the parents that are falling apart. So, I don't break character, I just try to do as much stupid stuff as I can to make them laugh."