The 47-year-old actress portrayed Pitt's mother in David Fincher's 2008 movie, The Curious Case of Benjamin Button, which earned her an Oscar nomination.
On Thursday's Watch What Happens Live With Andy Cohen, Henson was asked by a caller to share the most shocking thing she learned about the 54-year-old actor while working with him on the critically acclaimed movie.
"He is so down-to-Earth," Henson said in praise of Pitt. The Empire star also recalled that while filming Benjamin Button, the paparazzi "chased him, he and Cate [Blanchett], like crazy."
"He almost looked as if, 'Why are they chasing me? Why do they want pictures of me?' That's how humble he is," she continued. "He'd get thrown. ...He's a great guy."
Liam Neeson was also on WWHL and shared his own memories with Pitt. Though the two have yet to work together, the 65-year-old actor remembered when Pitt was dating Gwyneth Paltrow, and he visited his upstate home that he shared with his late wife, Natasha Richardson.
"I thought he was a lovely, lovely guy," Neeson said. "He's a wonderful guy and a fantastic actor. He doesn't get enough credit for his acting."