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ET was with a very young-looking, 16-year-old Neil Patrick Harris back in 1989, when he was gearing up to play Doogie Howser, M.D.

"They were looking for an unknown-ish, not a 'Kirk Cameron' face that everyone recognizes," said Neil about landing his gig after a casting effort all around the country and cattle call to find the ideal star.

"In the pilot, he's talking to his dad and he just wishes to be a normal kid, which is true for myself, and I'm sure a lot of child actors wish that they could start over again," said the busy teen, who would study for school during breaks from the set. "When you're a minor, you can only work so many hours a day."

"I'm real honored to be able to do it," said Neil of his job that would end up running for four seasons. "I think it's great, and I'm grateful that this has all turned out as it has."