"I just offhandedly mentioned to a friend, 'If I ever was offered that job, I'd take it in a minute,'" said Ashton. "And then when they offered me the job I was like, 'Whoa! ... That's good karma.'"
Ashton, now one of the highest paid actors on TV, plays an internet billionaire who goes to Jon Cryer's character for love advice after being heartbroken. Meanwhile, there's no love loss between the men of the show as they mercilessly teased each other during their time with Nancy.
"I can see this is working out really well - the chemistry here," Nancy commented.
Perhaps his co-stars are toughening Ashton's skin for the inevitable criticism he will face, whether good or bad, when the show comes back on the air.
"I don't think that there was a lot of pressure," Ashton said. "There's a reason why so many people watch [Men] and so many people love it and appreciate it - because it's written really well, it's acted really well ... I'm a tiny piece of that puzzle."
Two and a Half Men returns to CBS on Monday, September 19 at 9/8c.