Rob Lowe takes on the role of a lifetime, portraying President John F. Kennedy in the National Geographic Channel original movie Killing Kennedy, and he tells ET's Rocsi Diaz, "I look at J.F.K. as a Shakespearean character."
ET's Top 5: JFK Movies
"Larger than life, heroic, flawed, public figure, revolutionary, game changer -- so Shakespeare would have written him, and like a Shakespeare character, many actors will do him ... and I think it's up to each actor to bring their own personal take on him; he's our Hamlet," says Rob. "For me, what I was interested in was capturing him as a man. ... At the end of the day, he was just a man like any other, and I think this is a very honest look at what we lost 50 years ago this month in Dallas."
Based on the best-selling book Killing Kennedy: The End of Camelot by Bill O'Reilly and Martin Dugard, the film follows the trajectories of two men -- JFK and Lee Harvey Oswald – as they each head on a track that would alter the course of history, culminating in not one but two shocking deaths that stunned the nation. The film also stars Ginnifer Goodwin as Jacqueline Kennedy, Jack Noseworthy as Bobby Kennedy, Will Rothhaar as Lee Harvey Oswald and Michelle Trachtenberg as Marina Oswald.
Related Video: Rob Lowe Opens Up About Pressures of Playing JFK
Killing Kennedy airs November 10 at 8/7c on the Nat Geo Channel, just in time for the 50th anniversary of JFK's tragic assassination.