This Is What the 'Grey's Anatomy' Cast Looks Like 10 Years Later

by John Boone 1:26 PM PDT, March 27, 2015
Photo: ABC

Ten years, 11 seasons, and countless medical traumas, death scares, bomb threats, plane crashes, near-drownings, gunmen, weddings, babies, tears, and hospital hook-ups ago, we checked into Seattle Grace. Today, March 27, is the official 10-year anniversary of Grey’s Anatomy.

Here are the only five original characters still on the show in 2005 and now:

Ellen Pompeo as Meredith Grey

Photo: ABC

Patrick Dempsey as Derek Shepherd

Photo: ABC

Justin Chambers as Alex Karev

Photo: ABC

Chandra Wilson as Miranda Bailey

Photo: ABC

James Pickens Jr. as Richard Webber

Photo: ABC

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The rest of the original cast have left since Grey’s for other opportunities:

Sandra Oh as Cristina Yang

Photo: Warner Bros. Pictures

Oh left Grey Sloan Memorial Hospital after season 10 in 2014 and has since appeared in Melissa McCarthy’s maligned comedy Tammy.

Katherine Heigl as Izzie Stevens

Photo: NBC

Heigl left during the sixth season to make a handful of bad rom-coms and now stars as CIA analyst Charlie Tucker on State of Affairs.

T.R. Knight as George O’Malley

Photo: CBS

Knight was killed off at the end of season five and has since done a guest arc on The Good Wife and starred in the failed Amazon pilot, Hysterical.

Isaiah Washington as Preston Burke

Photo: The CW

Washington was fired in season three -- though he did return for an episode in the 10th season -- and now plays Chancellor Thelonious Jaha on The 100.

Find out why the Grey’s Anatomy actors would be horrible doctors in real life: