The Doubt star, donning a variety of revealing, mostly-leather outfits, took on the legendary role originated on screen by Tim Curry in the 1975 original, and made it all her own while staying true to what made Frank-N-Furter an indelible pop-culture icon.
While Victoria Justice and Ryan McCartan did their best as Janet and Brad (originally played by Susan Sarandon and Barry Bostwick), no one could hold a candle to Cox's show-stopping diva performance that carried the bulk of the film.
From her musical chops to her pitch-perfect reimagining of Frank-N-Furter's unique speech pattern, Cox brought a level of sexuality and dominance that allowed her interpretation to stand on its own without having to be judged in comparison to Curry's celebrated performance.
For his part, Curry actually appeared in the film as well, serving as the story's professorial narrator, The Criminologist (originally portrayed by Charles Gray).
Curry's appearance in the film -- which comes following a series of health problems, including a stroke he suffered in 2013 which has since confined him to a wheelchair -- was a sweet tribute to the actor's own legacy and career.
While the film stayed true to the source material in many important ways, it also paid service to the massive and long-standing cult fan base that has ensured the original film's longevity.
Throughout the two-hour story, the film would often cut to a shot of a wild, rowdy theater audience watching the movie on the big screen and reacting to events. It was an attempt by director Kenny Ortega to recreate the cult experience of watching the original at a revival screening, where viewers dress up as their favorite characters and vocally interact with the film as it goes along.
While the scenes with the audience didn't always work, and sometimes undercut otherwise fun or iconic moments by cutting away from the action, it was still a nice little homage to the culture of hardcore Rocky Horror fans who've been celebrating the musical horror comedy for over 40 years.
Meanwhile, a few other standout performances came from Penny Dreadful star Reeve Carney, who played a flawless Riff Raff, and Masters of Sex star Annaleigh Ashford, who killed it as the doomed Columbia. Both lived up to the stellar performances by Richard O'Brien and Nell Campbell from the original Rocky Horror.
Throughout the show, Cox took to Twitter to live-tweet the movie, share some behind-the-scenes snapshots from production and answer questions from fans.
ET caught up with the Orange Is the New Black star back in August, where she opened up about playing Dr. Frank-N-Furter, calling it "the scariest thing I've ever done in my life." Check out the video below to hear more.