If you're an Atlanta Falcons fan who believes in omens, you probably shouldn't watch this video.
After easily defeating O'Brien in the first round, Brady went up against Falcons defensive end, Dwight Freeney, who was still holding a grudge for all the times Brady beat him on the football field in the past.
Despite a valiant effort, Freeney's video game skills didn't match up to his athletic abilities, and he too fell Brady's onslaught of video game attacks.
"He won!" O'Brien, a New England native, proclaimed. "The Patriots won!"
Later, O'Brien called on Patriots tight end Rob Gronkowski and retired running back Marshawn Lynch to do battle. While Lynch lost pretty quickly to Gronk, he was still given a consolation trophy.
"I'm still receiving trophies even when I'm retired," Lynch joked.
Not to be outdone, Conan's rival late-night show, Jimmy Kimmel Live!, sent Guillermo to Super Bowl Media Night with some pretty funny results. Watch the video below!