Jamie Foxx, Emma Stone, Liam Hemsworth, Zendaya, Kevin James, Meghan Trainor, Nick Cannon, Debby Ryan, Quvenzhane Wallis, Fifth Harmony, Bethany Mota, Shawn Mendes and more are scheduled to appear at the event, and none of them are safe from the show's infamous green slime.
"If I can get any of them slimed, I will be very happy," Nick said.
Nick admitted to being a "rookie at the hosting thing," but as a three-time Kids' Choice nominee, he's well-acquainted with the show's format.
"It's going to be some new work, but overall I'm pretty familiar with how the show works and the vibe of it all, which is the most important thing," Nick said. "As long as you get up here and have fun, I think it's such a great night."
Nick could find himself up for a another Kids' Choice award next year in the acting category, as he's joined Ryan Murphy's horror comedy Scream Queens, coming soon to Fox.
"Very excited about Scream Queens," Nick told ET. "Kind of bouncing back and forth between shooting the show and some other things and it's great -- amazing cast. Ryan Murphy's such a visionary, and I think this is going to be a show that's going to surprise a lot of people. It is very top secret. I actually am not allowed to say anything more than I've already said, but my character, I think, will surprise a lot of people and Ryan is one of those guys who has such a clear vision for what he wants to accomplish and do, and the show's no exception."
According to Murphy, the horror comedy series (also featuring Lea Michele, Emma Roberts, Abigail Breslin, Ariana Grande and more) will center on the "world's meanest sorority" when a "series of bad things" begin to happen.
The Kids' Choice Awards airs Saturday, March 28 at 8 p.m. ET/PT on Nickelodeon.