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The show also included another awkward pairing, although not in the in the same category. Famous exes Justin Timberlake and Britney Spears won Favorite Male and Female Artist, respectively.
ET caught up with Horan, who released his first solo single, "This Town," in September, at the AMAs last fall, where he said he was looking forward to reuniting with Malik after the 24-year-old singer left 1D in 2015.