The Wrinkle in Time star had audiences both at the Beverly Hilton and at home moved to tears, as she delivered an acceptance speech that touched on African-American accomplishments, leadership, truth, abuse and power.
"Their time is up!" she strongly declared of the men and women using their positions to hurt others. "I want all the girls watching here now to know that a new day is on the horizon! And when that new day finally dawns, it will be because of a lot of magnificent women, many of whom are here tonight, and some pretty phenomenal men, fighting hard to make sure that they become the leaders who take us to the time when nobody has to say, 'Me too,' again!"
Empowering and emotional, Winfrey's speech left Hollywood with a lot of feelings -- which the camera crew luckily caught. There were nods:
And lots of applause.
And according to Ava DuVernay, the room was "still vibrating like electricity" after the speech had ended. See more celeb reactions below.