Kirstie has had one of the most public battles with weight. Kirstie's role as Rebecca Howe on Cheers made her a household name. After the show went off the air in 1993, Kirstie's career started to fizzle out and her weight began to balloon up. In 2005, she turned her weight struggle into a success story with the Showtime series Fat Actress. Eventually she was up to 219 pounds and became the spokeswoman for Jenny Craig. On that program, she lot 75 pounds. She even put on a bikini on Oprah to showcase her new body. But later she would gain the weight back, as documented on her 2010 reality show Kirstie Alley's Big Life. Recently she lost a significant amount of weight while on Dancing with the Stars.