Scott is survived by his two daughters, Taelor, 19 and Sydni, 15.
In July, Scott accepted the Jimmy V Perseverance Award at the ESPYs, and in his speech, he told his teenage daughters: "Taelor and Sydni, I love you guys more than I will ever be able to express. You two are my heartbeat. I am standing on this stage here tonight because of you."
During the moving speech, his words were touching and inspiring, "When you die, that does not mean that you lose to cancer. You beat cancer by how you live, why you live, and the manner in which you live," Scott said. "So live. Live. Fight like hell."
Many stars have used Twitter to share their sadness over Scott's passing.
My friend Stuart Scott passed today. My heart is broken for his 2 daughters and his entire family. I… http://t.co/V38bXc8epT