On Sunday, Padalecki's manager gave a statement to Zap2It, explaining that the 32-year-old actor had "pushed himself to his limits."
"Jared wanted everyone to know he loves meeting his fans around the world and was very upset at having to cancel his trips to Rome and Australia," the statement read. "Jared has pushed himself to his limits and is suffering from exhaustion. His SPN family is so important to him, and he asks that they Always Keep Fighting. At this time he needs to be home with his family."
Fans were quick to encourage Padalecki via Facebook and Twitter, sending him their thoughts and prayers.
On Monday, Padalecki responded in kind, thanking his fans for their support.
Thank you, from the bottom of my heart and soul, for your love and support. It's going to good use. All of my love and #AlwaysKeepFighting