This just may be a duo too explosive to handle.

Charlie Sheen expressed his interest in being Donald Trump's running mate on Thursday, after actor Owen Wilson called the 69-year-old Republican presidential hopeful the Charlie Sheen of politics in a recent interview.

"You can't help but get a kick out of him [Trump], and I think part of it is we're so used to politicians on both sides sounding like actors at press junkets -- it's sort of by rote, and they say all the right things," Wilson told The Daily Beast. "So here's somebody who's not following that script. It's like when Charlie Sheen was doing that stuff -- like, wow! He's answering a question completely honestly, and in an entertaining way. You sort of feel he could be a character from Network."

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It didn't take long for 49-year-old Sheen to respond, in the style of one of his epic poems.

"If Trump will hv me I'd be his VP in a heartbeat! #TrumpSheen16," he tweeted.

This marks a big change of tune from the former Two and a Half Men star's tweet last month, when he slammed the former Apprentice host in a way that only he could.

"Trump, you're a sad & silly homunculus," Sheen tweeted. "Your words as poignant as a sack of cat farts, You're a shame pile of idiocy."

We doubt Trump will be receptive to Sheen's interest in politics. In fact, it appears he's already got his hands full with an ongoing beef with Fox News anchor Megyn Kelly. "I liked The Kelly File much better without @megynkelly," the controversial celebrity billionaire tweeted on Monday when she returned to the show after an unplanned 10-day vacation. "Perhaps she could take another eleven day unscheduled vacation!"

FOX News Chairman and CEO, Roger Ailes, quickly defended the 44-year-old host.

"Donald Trump's surprise and unprovoked attack on Megyn Kelly during her show last night is as unacceptable as it is disturbing," Ailes wrote in a statement. "Megyn Kelly represents the very best of American journalism and all of us at FOX News Channel reject the crude and irresponsible attempts to suggest otherwise." 

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