"I didn't have postpartum the first time [with Olive] so I didn't understand it because I was like, 'I feel great,'" she reveals. "The second time [with Frankie], I was like, 'Oh, whoa, I see what people talk about now. I understand.' It's a different type of overwhelming with the second. I really got under the cloud."
Luckily, Barrymore says her postpartum was "short-lived, probably six months." Despite the hardship, the 40-year-old has been able to overcome it all and live a family life that she describes as "perfect and totally imperfect." She says she especially enjoys watching her husband play the role of dad.
"Honestly, I don't know how it is for other couples but really I like watching him be a father," Barrymore tells the magazine. "I know everyone says you're supposed to put your coupledom first. But I really love it being all about the kids. Maybe that's my compensating for not having parents myself or a childhood but right now, the focus is about how we're figuring things out as parents."
Barrymore isn't the only celebrity who has openly talked about suffering from postpartum depression. Last week, ET chatted with Gwyneth Paltrow at the La Mer Celebrates 50 Years of an Icon event in Los Angeles, where she reflected on her experience with the mood disorder after giving birth to her second child, Moses, in 2006.
"Luckily, [my case] was low grade enough that I didn't have to be hospitalized, but it's a very debilitating thing, and I think there's so much shame around it and there shouldn't be," Paltrow told ET. "It's something that happens, it's something that befalls many women after they have a baby, and for me, it ended up being a wonderful opportunity to explore some underlying issues that I think the depression kind of brought out."
Another star who can relate is Hayden Panettiere. The Nashville actress recently checked into treatment for postpartum depression, after giving birth to her first child, a daughter, Kaya, with her fiancé, Wladimir Klitschko, in December 2014.
"Hayden Panettiere is voluntarily seeking professional help at a treatment center as she is currently battling postpartum depression," the actress' rep confirmed to ET last week. "She asks that the media respect her privacy during this time."
For more on the 26-year-old's treatment check-in, watch the video below.