Weatherly has been a fan favorite on the popular CBS crime procedural since its inception in 2003. In 2014, Weatherly talked to ET about how the long-running series -- which spawned spinoffs NCIS: LA and NCIS: New Orleans -- has attained global popularity over the years.
"[People around the world] love the humor and the interaction between the characters," Weatherly said at the time. "It feels like a family, and it feels real. Or it feels like their work place… we don't just solve a crime, we fill in all that other stuff."
"This show has had to change over and over and over again," he added. "And that is really where the extraordinary value is."
Meanwhile, Weatherly's on-screen love interest, Ziva, was played by Cote De Pablo, who left the show to much fanfare in 2014. Could De Pablo return to see Weatherly off?
Watch the video below to see Weatherly talk about how NCIS meant so much to so many people.