After a law enforcement source told CBS News that prescription drugs were found in Prince's possession at the time of his death, ET has more insight into the music icon's alleged use of prescribed medicine.
A source close to the situation tells ET that Prince began taking Percocet in 2006 when his pain first started, adding that Prince had ankle and hip problems for years and had hip replacement surgery in 2010.
WATCH: Prescription Drugs Found With Prince at the Time of His Death
According to E!, a source claimed that Prince refused to have the needed blood transfusion during his surgery because it conflicted with his Jehovah's Witness beliefs, and used Percocet to cope with the discomfort.
Previously, Prince's longtime collaborator Sheila E. told ET that she had no knowledge of Prince taking pills, but did say that "he was in pain all the time."
WATCH: Prince Was Home Alone at Time of Death, No Signs of Suicide or Trauma, Sheriff Says
"I mean, you think about all the years he was jumping off those risers," she recalled. "They were not low -- they were very, very high -- and to jump off that ... First of all, the Purple Rain tour and the way that they were stacked, he had those heels on. We did a year of touring [and] for him to jump off of that -- just an entire year would have messed up his knees."
The Midwest Medical Examiner's office has not released any information about the singer's autopsy, which was performed on Friday, including whether or not toxicology reports indicate that drugs played a role in Prince's death.
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The singer was pronounced dead shortly after being found unresponsive in an elevator on his Paisley Park estate in Chanhassen, Minnesota, last Thursday. Just a week earlier, his plane was forced to make an emergency landing in Moline, Illinois, where he was transported to a nearby hospital.
According to TMZ, sources claimed the landing was in response to Prince suffering from a life-threatening Percocet overdose.