She added, "If you yell out again, you're going to be yelling 'show me your t*ts' to people in the parking lot, because you're gonna get thrown out mother f**ka."
Schumer even attempted to move on with the show, and did not immediately throw him out but let him off with a warning. However, when he yelled out another time, she had security escort the man out of the venue.
"Did you just yell out again? Oh, now it's time. Bye. I'm going to miss you so much," she quipped.
Schumer even had the audience clap for whether they thought he should leave or stay. The crowd overwhelmingly cheered for the man to leave the show.
The Trainwreck star is known for speaking her mind, and perhaps that's why Meryl Streep has said that she would like Schumer to play her in a biopic. Needless to say, the comedian was thrilled to hear this about the acclaimed actress.
"I shrieked," Schumer told ET. "There's just no higher praise from a higher person."