Justin Theroux on Divorce of Wife Jennifer Aniston's Ex Brad Pitt and Angelina Jolie: 'That's Terrible News fo

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Justin Theroux is sympathizing with Brangelina’s six children following their shocking divorce news.

The 45-year-old actor spoke out on the high-profile split between Angelina Jolie and Brad Pitt, his wife Jennifer Aniston’s ex-husband.

WATCH: Brad Pitt Hoping to See His Kids Soon and Resolve Matters 'Amicably' in Angelina Jolie Divorce

“As a child of divorce, all I can say is that's terrible news for those children and that's all you can really say," Theroux compassionately tells Business Insiderwith regard to Maddox, 15, Shiloh, 10, Pax, 12, Zahara, 11, and twins Vivienne and Knox, 8. "It's boring to sort of comment on anything else. People are having a bad time, that's horrible.”

Jolie and Pitt, who co-starred in 2005's Mr. and Mrs. Smith, quickly became an item after Pitt’s divorce from Aniston that same year, drawing tons of public interest around their personal lives.

Jolie filed paperwork to end their two-year marriage last Monday after 12 years together.

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Despite the fact that Pitt and Aniston cut ties well over a decade ago, the Internet was quick to involve Theroux’s wife, imagining her reaction to her ex-husband’s second divorce.

MORE: Jennifer Aniston and Justin Theroux Have a Night in With Emily Blunt and John Krasinski

"There's an endless appetite for trash, apparently, though everyone would say that they don't have that appetite. But I think a lot of people do because people buy it," Theroux adds, calling it "nonsense" that Aniston’s name has been brought into the divorce drama, the site notes.

"But there are bigger things to b**ch about," he says. "It's shocking how much bandwidth things can take up when there are far more important things going on in the world."

When ET caught up with Theroux during his press tour for his latest film, The Girl on the Train, he couldn’t help but gush over how his relationship with Aniston works.

MORE: EXCLUSIVE: Justin Theroux on Why He and Jennifer Aniston Are So Good Together: 'We Get Along'

"We appreciate each other's sense of humor, we respect one another and we get along," he told ET's Nischelle Turner of the 47-year-old actress, whom he began dating in 2011 and wed last year.

"I know it sounds simple but it's true!" Theroux exclaimed.

For more on the happy couple, watch below: