Inside the magazine, she poses for a stunning black-and-white shot with her younger brother, 17-year-old Anwar Hadid, which was shot by famed photographer Mario Testino.
She also gets candid on her relationship with boyfriend Zayn Malik, telling the high-fashion glossy the two prefer staying in over going out.
"When I'm in Los Angeles I mostly stay in because it's my time off and I like being with my boyfriend and doing art and cooking," she explains. "We like late-night movies and we order from this amazing place that does lattes and gingerbread cookies."
"I need coffee to stay up. I'm always like, 'Babe, let's go to a movie,'" she says. "Then I fall asleep halfway through and he's like, 'You've seen the first half of every movie out there and you have no idea how any of them end.'"
Hadid also opens up about the reaction she received for the inspiring letter she penned about body shaming via Instagram back in September 2015.
"The response was crazy," she dishes. "From Victoria's Secret Angels to my friends who are considered plus size, everyone texted me and said they appreciated me saying something."
"The world puts so much pressure on fashion, then judges models for succumbing to that pressure," she adds.
Following the release of her latest British Vogue cover, the blond beauty took to Instagram to gush over the beautiful photo shoot, writing, "Truly grateful and honored to have shot my second @britishvogue cover !! It's still an honor in itself to spend a day with #lucindachambers @mariotestino @tompecheux @orlandopita ! Thanks for a lovely one my friends! On stands Friday - Feb 3rd!! xx."
"Welcoming my lil bruv to @britishvogue !!" another post read. "HE'S SO GROWN UP & IM SO PROUD !!! @anwarhadid by @mariotestino."