The 41-year-old actress, who starred for 10 years on ABC's Grey's Anatomy, took to Twitter on Thursday to slam the network for a joke about bisexual people that aired during a recent episode of The Real O'Neals.
On the episode in question, which aired on Jan. 17, Noah Galvin's openly gay character, Kenny, compared being bisexual to having "webbed toes" or "money problems."
Ramirez, who played bisexual character Callie Torres on Grey's, and identifies as bisexual herself, said that she was "truly disheartened and disappointed" by the joke, and that she would "invest my brand where I'm respected."
The actress addressed ABC and The Real O'Neals in her tweet, encouraging them to "own" and "address" the mistake, to "empower our #Queer and #Bisexual youth & community w/accurate positive reflections." She also asked fans to sign a Change.org petition imploring ABC to "end biphobia and bi-erasure" on the comedy.
The Real O'Neals star, who found himself surrounded by controversy last year after slamming Eric Stonestreet's portrayal of a gay man on Modern Family and mocking Colton Haynes' decision to come out as gay, addressed the joke last month on Twitter.
The 22-year-old actor said he "respects and loves the bi community," though defended the joke, saying it represented "a panicky teen expressing his 'deepest fear' which was his boyfriend leaving him for a girl." "I'm sorry if we offended anyone. I hope you know our show fights for visibility and inclusivity and we will do better in the future. BUT, we also have to remember, it's a comedy."